From Harrisonburg:
Begin traveling on I-81 S toward Staunton. Next take exit 221 toward Richmond. Then take exit 99 toward Afton/Charlottesville, travel for about 1.9 miles to make a right onto VA-151, after about 3.7 miles make a right onto Patrick Henry Hwy, travel on this for about 6 miles, turn left onto Pike Rd. Then turn right onto US-29 S for about 37.4 miles, take US-460 W toward Danville for 13.3 miles. At Jackson Rd make a U-turn onto US-460 E travel for 1 tenth of a mile to end at 13001 E. Lynchburg Salem Tpke.

From Richmond:
Begin traveling on I-195 N. (portions toll) Keep left to take VA-146 S for about .9 miles. VA-146 S becomes VA-76 S, travel here for about 10.6 miles, merge onto VA-288 S for a total of 2.7 miles. Then take US-360 W toward Amelia for about 31.3 miles; make a slight right for about .1 mile, before making another slight right onto VA-307 for about 9.1 miles. Next, take US-460 W for about 64.3 miles, U-turn at Jackson Rd onto US-460 E., less than 1 tenth of a mile where you will end at 13001 E. Lynchburg Salem Tpke

From Danville:
Begin traveling on US-29 N. Then take the VA-714 ramp toward Altavista for about .3 miles, turn left onto Lynch Mill rd. Lynch Mill Rd becomes Goodman Crossing Rd, this becomes Leesville Rd. After about 7.8 miles turn left onto VA-24 travel for .5 miles to make a right onto Evington Rd, after 4.3 miles turn right onto New London Rd. Then take US-460 E for about .9 miles to end at 13001 E. Lynchburg Salem Tpke

From Blacksburg:
Begin traveling on I-81 N. Then take exit 150A. Next, turn left onto US-221 N and follow for 21 miles to US-460 E toward Lynchburg, travel for about 15 miles to end at 13001 E. Lynchburg Salem Tpke